COMPLEMENT-MEDIATED HISTAMINE RELEASE FROM HUMAN LEUKOCYTES
نویسندگان
چکیده
منابع مشابه
Histamine release from human leukocytes when stimulated by Mycoplasma salivarium.
Incubated mixtures of Mycoplasma salivarium and nonsensitized mixed leukocytes released histamine. Spectrophotofluorometric detection of histamine occurred at physiological temperature and pH independent of complement and specific antiserum.
متن کاملAn inhibitor of histamine release from human leukocytes.
Lysates of human leukocytes, prepared by ultrasonic disruption, contained heat-labile histamine-releasing factors. An inhibitor of histamine release was generated from such lysates during thermal inactivation of the histamine-releasing activity. Lysates inactivated at 38 degrees C for 60 min produced up to 90% inhibition of histamine release from human leukocytes. Heated lysates produced signif...
متن کاملAnaphylatoxin-induced histamine release with human leukocytes: studies of C3a leukocyte binding and histamine release.
Purified human C3a and synthetic COOH-terminal peptides of C3a, i.e., a pentapeptide, Leu-Gly-Leu-Ala-Arg (5R), and an octapeptide, Ala-Ala-Ala-Leu-Gly-Leu-Ala-Arg (8R) induced histamine release from human basophil granulocytes. On a molar basis, 5R was one-tenth and 8R was one-fifth as active as C3a in causing histamine release. It was found that 125I-C3a binds to whole leukocytes, interacting...
متن کاملHistamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier.
Cytochalasin B, a metabolic product of several fungi, enhances up to 10-fold the sensitivity and reactivity of human leukocytes to antigen E or anti-IgE-mediated histamine release. The effect of cytochalasin B is a result of its action on the second, antigen-independent, stage of histamine release. These data suggest that normally, antigen-triggered histamine release is modulated by a cytochala...
متن کاملStaphylococcus aureus peptidoglycan induces histamine release from basophil human leukocytes in vitro.
Whole killed cells, cell walls, and peptidoglycans of Staphylococcus aureus were found to release histamine from human leukocytes and isolated rat mast cells in vitro. The histamine-releasing capability increased in the order of whole bacteria, cell walls, and peptidoglycans. Peptidoglycan was found to release histamine by a nonimmunological mechanism, as demonstrated by release in cells depriv...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1974
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197404000-00431